Physiological responses to leptin levels in lipodystrophy: a model for other hypoleptinemias?
نویسندگان
چکیده
منابع مشابه
Leptin: a novel therapeutic role in lipodystrophy.
Lipodystrophic syndromes encompass a heterogeneous group of rare disorders characterized by partial or generalized loss of adipose tissue depots (1). They are commonly associated with dyslipidemia, hepatic steatosis, and severe insulin resistance (2). The fact that insulin resistance and the consequent progression to diabetes can result from either obesity or lipodystrophy reflects the crucial ...
متن کاملLeptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome
Leptin, an adipocyte-secreted hormone, regulates energy homeostasis as well as reproductive, neuroendocrine, immune and metabolic functions. Subjects with decreased amounts of fat in their adipose tissue, i.e., lipoatrophy, have low leptin levels. In the context of open-label, uncontrolled studies leptin administration, in physiological replacement doses, has been shown to have metabolically sa...
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To investigate the physiological responses of sunflower (Helianthus annuus L., Alstar hybrid) to water stress under different levels of zinc fertilizer, an experiment was conducted at the Isfahan Agricultural Research Center, Isfahan, Iran, during 2008 and 2009 using a randomized complete block design within a split plot layout with three replications. Five irrigation treatments used in thi...
متن کاملAdiponectin and leptin levels in HIV-infected patients with lipodystrophy in Southern India
Methods In this cross sectional study, consenting 79 HIV+ve patients on antiretroviral therapy (for more than six months) visiting the Namakkal Government Hospital were recruited. Demography, anthropometry and ART regimens were collected. Patients’ self-perception of lipodystrophy was determined using standardized questionnaires and clinically confirmed. An overnight fasting blood was drawn to ...
متن کاملPOMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels
Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin's actions are mediated through pro-opiomelanocortin (POMC) neurons that express leptin receptors (LEPRs). However, previous studies have used prenatal genetic manipulations, which may be subject to developmental compensation. Here, we...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2018
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci122042